Description

5-Methyl-Pyrimidine-2-Sulfonyl Fluoride is a high-purity, reactive sulfonyl fluoride derivative used as a key building block in advanced organic synthesis. This compound is valued for its role as a selective sulfonylation reagent, enabling the efficient introduction of the sulfonyl fluoride functional group into target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and chemical probes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Chemical Biology Probe Synthesis: Used to create activity-based probes (ABPs) for studying enzyme function and target engagement through covalent modification.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Employed in the research and development of specialty polymers and advanced functional materials.
• Sulfonyl Fluoride Library Construction: Essential for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	5-Methyl-Pyrimidine-2-Sulfonyl Fluoride
CAS No.	35762-75-5
Molecular Formula	C5H5FN2O2S
Molecular Weight	176.17 g/mol
Synonyms	2-Pyrimidinesulfonyl fluoride, 5-methyl-; 5-Methyl-2-pyrimidinesulfonyl fluoride; 5-Methylpyrimidine-2-sulfonyl fluoride; 2-(Fluorosulfonyl)-5-methylpyrimidine; 5-Methyl-2-sulfonylfluoropyrimidine; 5-Methylpyrimidin-2-ylsulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 5-Methyl-Pyrimidine-2-Sulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.