Description

4-Methyl-Pyrimidine-2-Sulfonyl Fluoride is a specialized organosulfur building block featuring a reactive sulfonyl fluoride group. This compound is valued for its role as a key intermediate in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working in medicinal chemistry, where it is used to introduce the sulfonyl fluoride moiety into target structures for applications such as covalent inhibitor development and chemical probe synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting enzymes via covalent inhibition.
• Medicinal Chemistry Research: Used in the discovery and optimization of new therapeutic agents, enabling the introduction of the sulfonyl fluoride group for creating targeted covalent inhibitors.
• Chemical Biology Probes: Serves as a precursor for developing activity-based probes (ABPs) used to study enzyme function and target engagement in biological systems.
• Agrochemical Synthesis: An intermediate in the production of advanced herbicides, fungicides, and insecticides that incorporate pyrimidine scaffolds.
• Material Science: Potential use in the synthesis of functional polymers and advanced materials where the sulfonyl fluoride group can act as a reactive handle for further modification.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in various metal-catalyzed and metal-free reactions to form carbon-sulfur bonds.

Basic Information

Product Name	4-Methyl-Pyrimidine-2-Sulfonyl Fluoride
CAS No.	35762-74-4
Molecular Formula	C5H5FN2O2S
Molecular Weight	176.17 g/mol
Synonyms	2-Pyrimidinesulfonyl fluoride, 4-methyl-; 4-Methyl-2-pyrimidinesulfonyl fluoride; 4-Methylpyrimidine-2-sulfonyl fluoride; 2-(Fluorosulfonyl)-4-methylpyrimidine; 4-Methyl-2-sulfonylfluoropyrimidine; 4-Methylpyrimidine-2-sulfonylfluoride; 4-Methyl-2-pyrimidinesulphonyl fluoride
EINECS	Contact for details

Quality Control

Our 4-Methyl-Pyrimidine-2-Sulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.