Description

Dl-4-Hydroxyphenylalanine-15N is a stable isotope-labeled analog of the amino acid tyrosine, where the nitrogen atom is enriched with the 15N isotope. This compound is a critical tool in advanced research, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR spectroscopy. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on drug discovery and biochemical pathway analysis.

Application

• Isotopic Tracer Studies: Used as an internal standard in quantitative mass spectrometry for accurate measurement of tyrosine and related metabolites.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for tracking the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds in preclinical research.
• Biochemical Pathway Analysis: Investigates tyrosine metabolism, protein synthesis, and neurotransmitter production in cellular and animal models.
• Proteomics and Metabolomics Research: Facilitates the identification and quantification of proteins and metabolites in complex biological samples.
• NMR Spectroscopy: Serves as a labeled substrate to elucidate molecular structures and dynamic processes in solution.
• Quality Control Reference Standard: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating methods in regulatory environments.

Basic Information

Product Name	Dl-4-Hydroxyphenylalanine-15N
CAS No.	35693-13-1
Molecular Formula	C9H1115NO3
Molecular Weight	182.19 g/mol (for 15N labeled form)
Synonyms	DL-4-Hydroxyphenylalanine-15N; DL-Tyrosine-15N; (±)-4-Hydroxyphenylalanine-15N; 3-(4-Hydroxyphenyl)-2-aminopropanoic acid-15N; DL-α-Amino-4-hydroxybenzenepropanoic acid-15N; DL-β-(4-Hydroxyphenyl)alanine-15N; 15N Labeled DL-Tyrosine; Tyrosine (DL, 15N)
EINECS	Contact for details

Quality Control

Our Dl-4-Hydroxyphenylalanine-15N is manufactured under strict quality systems to ensure high isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 15N), chemical purity by HPLC, and confirmation of structure. We support compliance with relevant research standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 15N)	≥ 98%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.