Description

Lhrh, Lys(8)- CAS NO 35544-05-9 is a synthetic peptide analog of luteinizing hormone-releasing hormone (LHRH), specifically modified at the 8th position with a lysine residue. This modification is critical for enhancing its stability and biological activity profile, making it a valuable tool for advanced research and development. It is primarily utilized in the pharmaceutical and biotechnology sectors for applications in endocrinology research, drug discovery, and the development of therapeutic analogs. The compound's specific structure allows for targeted studies on hormone regulation and receptor interactions.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of LHRH-based therapeutics.
• Endocrinology Studies: Used in biochemical and physiological research to investigate the hypothalamic-pituitary-gonadal axis, hormone release mechanisms, and receptor binding studies.
• Peptide Drug Discovery: Acts as a crucial building block or analog for designing novel peptide drugs with modified pharmacokinetic properties.
• Bioconjugation & Labeling: The lysine modification provides a reactive amine group for conjugation with fluorescent dyes, affinity tags, or other molecules for diagnostic or tracking purposes.
• In Vitro Bioassays: Employed in cell-based assays and high-throughput screening (HTS) platforms to evaluate biological activity and potency.
• Academic Research: Utilized in university and institutional labs for fundamental studies in reproductive biology, neuroendocrinology, and peptide science.

Basic Information

Product Name	Lhrh, Lys(8)- CAS NO 35544-05-9
CAS No.	35544-05-9
Molecular Formula	C59H84N18O13
Molecular Weight	1229.4 g/mol
Synonyms	Lys8-LHRH; [Lys8]-Luteinizing Hormone-Releasing Hormone; Luliberin, 8-L-lysine-; Gonadorelin, 8-L-lysine-; LHRH (8-Lys); Pyro-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (Lys8); LH-RH, Lys8-; Factrel, Lys8 analog
EINECS	Contact for details

Quality Control

Our Lhrh, Lys(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	≤ 15.0%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.