Description

3β-[[8-[[(S)-4-[(Aminoiminomethyl)Amino]-1-Carboxybutyl]Amino]-1,8-Dioxooctyl]Oxy]-14-Hydroxy-5β-Bufa-20,22-Dienolide is a complex bufadienolide derivative, a class of compounds known for their potent biological activity. This high-purity intermediate is critical for advanced pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of specialized cardiovascular and oncological treatments. The compound's unique structure offers a valuable scaffold for medicinal chemistry and targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel bufadienolide-based drug candidates.
• Cardiovascular Research: Used in preclinical studies to investigate compounds with potential inotropic or anti-arrhythmic activity.
• Oncology Research: Serves as a precursor for developing cytotoxic agents targeting specific cancer cell pathways.
• Medicinal Chemistry: Provides a complex, functionalized core structure for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Research: Employed as a tool compound to study Na+/K+-ATPase inhibition and related cellular signaling mechanisms.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3β-[[8-[[(S)-4-[(Aminoiminomethyl)Amino]-1-Carboxybutyl]Amino]-1,8-Dioxooctyl]Oxy]-14-Hydroxy-5β-Bufa-20,22-Dienolide
CAS No.	35455-33-5
Molecular Formula	C39H57N5O9
Molecular Weight	739.91 g/mol
Synonyms	14-Hydroxy-3β-[[8-[[(4S)-4-[(aminoiminomethyl)amino]-1-carboxybutyl]amino]-1,8-dioxooctyl]oxy]-5β-bufa-20,22-dienolide; Bufadienolide derivative; Bufalin arginine derivative; Bufalin-3-hemisuccinate-arginine conjugate; 3β-O-(8-[[(S)-4-(Amidinoamino)-1-carboxybutyl]amino]-1,8-dioxooctyl)-14-hydroxybufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our 3β-[[8-[[(S)-4-[(Aminoiminomethyl)Amino]-1-Carboxybutyl]Amino]-1,8-Dioxooctyl]Oxy]-14-Hydroxy-5β-Bufa-20,22-Dienolide is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and analytical method validation where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.