Description

p-(2-Acetamidoethyl)Benzenesulphonyl Chloride is a specialized sulfonyl chloride derivative, a key reactive intermediate in organic synthesis. Its primary value lies in its role as a versatile building block for introducing the sulfonamide functional group, which is critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly those focused on developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially those containing sulfonamide moieties with potential therapeutic applications.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the sulfonamide group is a key pharmacophore.
• Peptide Modification & Bioconjugation: Serves as a reagent for selectively modifying amino groups on peptides, proteins, or other biomolecules to create conjugates or probes.
• Material Science Research: Employed in the synthesis of functional polymers, dyes, and advanced materials that require sulfonamide linkages for specific properties.
• Chemical Biology Tool Development: Utilized to create activity-based probes or affinity labels for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses producing high-value, low-volume specialty chemicals for clients.

Basic Information

Product Name	p-(2-Acetamidoethyl)Benzenesulphonyl Chloride
CAS No.	35450-53-4
Molecular Formula	C10H12ClNO3S
Molecular Weight	261.72 g/mol
Synonyms	4-(2-Acetamidoethyl)benzenesulfonyl chloride; N-[2-(4-Chlorosulfonylphenyl)ethyl]acetamide; p-(2-Acetamidoethyl)phenylsulfonyl chloride; 4-(2-Acetamidoethyl)phenylsulfonyl chloride; 1-[2-(4-Chlorosulfonylphenyl)ethyl]ethan-1-imine; (4-(2-Acetamidoethyl)phenyl)sulfonyl chloride; Acetamide, N-[2-(4-chlorosulfonylphenyl)ethyl]-
EINECS	Contact for details

Quality Control

Every batch of p-(2-Acetamidoethyl)Benzenesulphonyl Chloride is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.