Description

Fenoprofen Acyl-β-D-Glucuronide is a major Phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) fenoprofen. This compound is of critical importance in pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies. It serves as a key reference standard for analytical method development and validation in bioanalytical laboratories. Professionals in pharmaceutical R&D, contract research organizations (CROs), and academic institutions require this high-purity metabolite for accurate drug metabolism and safety profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantifying fenoprofen metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance rates, and bioavailability of fenoprofen.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, or LC-MS/MS methods for pharmacokinetic and toxicokinetic assays.
• Toxicology and Safety Assessment: Employed in studies to understand the role of glucuronidation in fenoprofen's safety profile and potential drug-drug interactions.
• Enzyme Kinetics Research: Serves as a substrate or product in studies of UDP-glucuronosyltransferase (UGT) enzyme activity and specificity.
• Impurity Profiling: Used as an impurity marker in the quality control of fenoprofen active pharmaceutical ingredient (API) to ensure product purity and safety.

Basic Information

Product Name	Fenoprofen Acyl-β-D-Glucuronide
CAS No.	35440-36-9
Molecular Formula	C24H26O10
Molecular Weight	474.46 g/mol
Synonyms	Fenoprofen Glucuronide; Fenoprofen Acyl Glucuronide; (RS)-Fenoprofen β-D-Glucuronide; dl-Fenoprofen Acyl-β-D-Glucuronide; 2-(3-Phenoxyphenyl)propionic acid 1-(β-D-glucopyranuronosyl) ester; Fenoprofen 1-O-β-Acylglucuronide; Fenoprofen β-1-O-Acyl Glucuronide; NSC 113927
EINECS	Contact for details

Quality Control

Our Fenoprofen Acyl-β-D-Glucuronide is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure identity, purity, and stability. A comprehensive Certificate of Analysis (COA) is provided, detailing results for assay, purity, and related substances. We adhere to relevant quality guidelines to ensure the material's suitability as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.