Description

2,4-Difluoro-Pyridine is a versatile fluorinated heterocyclic building block essential for advanced chemical synthesis. This compound matters for its role in introducing fluorine atoms and the pyridine scaffold into target molecules, enabling the fine-tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule drugs where fluorine substitution is critical.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the pyridine core for biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating novel ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, organic semiconductors, and polymers with specific electronic properties.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Functional Group Transformation: Used in nucleophilic aromatic substitution reactions, allowing for the selective introduction of other functional groups.

Basic Information

Product Name	2,4-Difluoro-Pyridine
CAS No.	34941-90-7
Molecular Formula	C5H3F2N
Molecular Weight	115.08 g/mol
Synonyms	2,4-Difluoropyridine; Pyridine, 2,4-difluoro-; 2,4-Difluoro-pyridin; 2,4-Difluorpyridin; 2,4-F2Py; 2,4-DFP; NSC 523806; AI3-52296
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-Pyridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from heat and ignition sources. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.