Description

Carbonochloridic Acid, 4-(Trifluoromethyl)Phenyl Ester is a specialized organic intermediate featuring a reactive chloroformate group and a trifluoromethylphenyl moiety. This compound is valued for its role as a versatile building block in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for constructing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group is a critical pharmacophore.
• Polymer Chemistry: Serves as a monomer or modifying agent for introducing functional groups into polymer chains to alter surface properties or reactivity.
• Liquid Crystal & OLED Material Research: Employed in the development of fluorinated organic electronic materials due to its electron-withdrawing trifluoromethyl group.
• Peptide & Protein Modification: The chloroformate group can be used for carboxyl group activation or as a protecting group strategy in peptide synthesis.
• Cross-coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions to form biaryl structures common in many functional molecules.

Basic Information

Product Name	Carbonochloridic Acid, 4-(Trifluoromethyl)Phenyl Ester
CAS No.	34857-66-4
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	4-(Trifluoromethyl)phenyl chloroformate; p-Trifluoromethylphenyl chloroformate; 4-Trifluoromethylphenyl chlorocarbonate; Chloroformic acid 4-(trifluoromethyl)phenyl ester; α,α,α-Trifluoro-p-cresyl chloroformate; 1-(Chloroformyloxy)-4-(trifluoromethyl)benzene; (4-Trifluoromethylphenoxy)carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of Carbonochloridic Acid, 4-(Trifluoromethyl)Phenyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for synthetic applications. Each lot is analyzed via modern chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.