Description

Dansyl Fluoride is a specialized fluorinated derivative of dansyl chloride, widely recognized as a critical derivatization reagent in analytical chemistry. Its primary value lies in its high reactivity as a fluorogenic labeling agent, enabling the sensitive detection and quantification of amines, amino acids, and other nucleophilic compounds. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors who require precise analytical methods for compound identification and purity assessment.

Application

• Derivatization Agent for HPLC & LC-MS: Used as a pre-column derivatization reagent to enhance the detection sensitivity of amines, amino acids, and peptides in chromatographic analysis.
• Fluorescent Labeling in Proteomics: Employed for tagging proteins and peptides to facilitate fluorescence-based detection, quantification, and imaging in biochemical research.
• Biomarker Analysis: Applied in clinical and diagnostic research for the derivatization and subsequent analysis of biomarkers in complex biological matrices.
• Pharmaceutical Impurity Profiling: Utilized in the identification and quantification of trace-level genotoxic impurities and other reactive species in active pharmaceutical ingredients (APIs).
• Food & Beverage Testing: Aids in the analysis of amino acids, biogenic amines, and other nitrogenous compounds for quality and safety control.
• Reagent in Chemical Synthesis: Serves as a building block or intermediate in the synthesis of more complex fluorescent dyes and probes.

Basic Information

Product Name	Dansyl Fluoride
CAS No.	34523-28-9
Molecular Formula	C12H12FNO2S
Molecular Weight	253.29 g/mol
Synonyms	5-(Dimethylamino)naphthalene-1-sulfonyl fluoride; Dansyl fluoride; DNS-F; 1-Dimethylaminonaphthalene-5-sulfonyl fluoride; DANSYL-F; 5-Dimethylamino-1-naphthalenesulfonyl fluoride; Danfluor; 1-Naphthalenesulfonyl fluoride, 5-(dimethylamino)-
EINECS	Contact for details

Quality Control

Our Dansyl Fluoride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and KF titration for moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.