Description

Clozapine n-Oxide CAS NO 34233-69-7 is a high-purity chemical intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a key precursor in the synthesis of innovative neuropharmacological agents and is a critical tool compound in chemogenetic technologies like Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). It is primarily sought by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in neuroscience, antipsychotic drug development, and cutting-edge biomedical research.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis and development of novel antipsychotic medications and related active pharmaceutical ingredients (APIs).
• Chemogenetics Research: Acts as the inert ligand (or "designer drug") for activating engineered DREADDs, enabling precise control of neuronal activity in vivo for neuroscience studies.
• Biomedical Research: Used as a reference standard and tool compound in pharmacological assays and metabolic pathway studies related to clozapine.
• Metabolite Studies: Employed in analytical research to study the metabolism, pharmacokinetics, and safety profile of the parent drug, clozapine.
• Fine Chemical Synthesis: Serves as a building block for the custom synthesis of specialized derivatives for structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	Clozapine n-Oxide
CAS No.	34233-69-7
Molecular Formula	C18H19ClN4O
Molecular Weight	342.82 g/mol
Synonyms	Clozapine N-Oxide; Clozapine Oxide; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine 5-Oxide; CNO (DREADD Ligand); 5H-Dibenzo[b,e][1,4]diazepin-5-one, 8-chloro-11-(4-methyl-1-piperazinyl)-; ACPD; Clozapine metabolite N-oxide
EINECS	Contact for details

Quality Control

Our Clozapine n-Oxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.