Description

S-(-)-Cotinine Methiodide is a high-purity, enantiomerically pure derivative of cotinine, a major metabolite of nicotine. This compound is a critical reference standard and intermediate in advanced pharmaceutical and biochemical research, particularly in studies related to nicotinic acetylcholine receptors. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors requiring precise chiral molecules for analytical method development, metabolic studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the quantification and validation of analytical methods (e.g., HPLC, LC-MS) in pharmacokinetic and metabolic studies.
• Biochemical Research: Serves as a key tool compound for investigating the binding affinity, metabolism, and functional role of nicotinic acetylcholine receptor (nAChR) subtypes.
• Diagnostic Reagent Development: Employed in the development and calibration of immunoassays and other diagnostic tests for nicotine exposure and metabolism.
• Organic Synthesis Intermediate: Acts as a chiral building block for the synthesis of more complex molecules targeting neurological pathways.
• Metabolite Studies: Utilized in in vitro and in vivo studies to understand the metabolic fate and biological activity of nicotine and related alkaloids.

Basic Information

Product Name	S-(-)-Cotinine Methiodide
CAS No.	33952-07-7
Molecular Formula	C11H15IN2O
Molecular Weight	318.16 g/mol
Synonyms	(S)-(-)-Cotinine methiodide; (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone methiodide; (-)-Cotinine methiodide; S-Cotinine methiodide; L-Cotinine methiodide; Cotinine methiodide (S-enantiomer); 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone, methiodide, (5S)-
EINECS	Contact for details

Quality Control

Our S-(-)-Cotinine Methiodide is manufactured under strict quality control protocols to ensure exceptional purity and enantiomeric excess suitable for research and development. Each batch is characterized using advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity is provided with every shipment to guarantee reproducible results and regulatory compliance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.