Description

o-Tolylmagnesium Chloride is a versatile organometallic reagent, specifically an aryl Grignard reagent, widely used in organic synthesis. Its primary value lies in its ability to act as a powerful nucleophile and strong base, enabling the efficient formation of new carbon-carbon bonds. This compound is particularly essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to construct complex molecular architectures. Handling requires strict adherence to protocols due to its reactive nature.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for introducing the o-tolyl (2-methylphenyl) moiety into active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Production: Used in the manufacture of herbicides, fungicides, and insecticides that require specific aryl group functionalization.
• Fine Chemical and Specialty Chemical Manufacturing: Employed in the synthesis of dyes, pigments, liquid crystals, and other performance chemicals.
• Cross-Coupling Reactions: Serves as a critical reagent in Kumada, Negishi, and other transition-metal catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Addition to Carbonyls: Reacts with aldehydes, ketones, esters, and carbon dioxide to produce secondary/tertiary alcohols and carboxylic acids.
• Polymer Chemistry: Can be utilized to initiate polymerization or incorporate aromatic units into polymer backbones for material science applications.
• Academic and R&D Laboratories: A fundamental tool for methodological development and exploratory synthesis in organic chemistry.

Basic Information

Product Name	o-Tolylmagnesium Chloride
CAS No.	33872-80-9
Molecular Formula	C7H7ClMg
Molecular Weight	150.89 g/mol
Synonyms	(2-Methylphenyl)magnesium chloride; 2-Methylphenylmagnesium chloride; 2-Tolylmagnesium chloride; o-Methylphenylmagnesium chloride; Magnesium, chloro(2-methylphenyl)-; Grignard reagent o-tolylMgCl; o-Tolyl-MgCl
EINECS	Contact for details

Quality Control

Our o-Tolylmagnesium Chloride is produced and handled under stringent quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Quality is typically assessed via titration to determine the concentration of the active Grignard reagent in solution. Certificates of Analysis (COA) detailing assay, purity, and solution concentration are provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. For solutions, typical recommended storage temperature is between 2°C and 8°C. Keep away from heat, sparks, open flames, and incompatible materials such as water, alcohols, acids, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Brown to dark brown solution
Concentration (in THF or Ether)	Typically 0.5 M to 2.0 M
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR / NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.