Description

4-Cyanobenzenesulfonyl Fluoride is a versatile and high-value aromatic sulfonyl fluoride derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in its dual functionality, where the sulfonyl fluoride group acts as a highly selective and stable electrophile for SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry, and the cyano group offers a handle for further derivatization. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity intermediates for constructing complex molecules and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and protease inhibitors.
• SuFEx Click Chemistry: Serves as a stable and selective electrophilic coupling partner for the rapid and reliable construction of sulfonate ester and sulfonamide linkages under mild conditions.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides that incorporate sulfonyl fluoride or sulfonamide moieties for enhanced activity.
• Polymer & Materials Science: Functional monomer for creating specialty polymers with tailored surface properties, adhesion, or chemical resistance.
• Chemical Biology & Proteomics: Employed as a activity-based probe (ABP) for labeling and studying serine hydrolases and other enzymes in complex biological systems.
• Ligand & Catalyst Development: Precursor for synthesizing sophisticated ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	4-Cyanobenzenesulfonyl Fluoride
CAS No.	33719-37-8
Molecular Formula	C7H4FNO2S
Molecular Weight	185.17 g/mol
Synonyms	p-Cyanobenzenesulfonyl Fluoride; 4-Fluorosulfonylbenzonitrile; Benzonitrile, 4-(fluorosulfonyl)-; 1-Cyano-4-fluorosulfonylbenzene; 4-(Fluorosulfonyl)benzonitrile; p-Fluorosulfonylbenzonitrile; 4-Cyanophenylsulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 4-Cyanobenzenesulfonyl Fluoride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.