Description

4-Bromo-2,3,5,6-tetrafluorotoluene is a high-purity fluorinated aromatic building block, essential for introducing both bromine and fluorine substituents into complex molecular architectures. This compound matters for its unique reactivity profile, where the bromine atom serves as a versatile handle for cross-coupling reactions, while the electron-withdrawing fluorine atoms significantly influence the electronic properties of the resulting materials. It is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced, high-performance pesticides and herbicides with improved environmental profiles.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds that enhance the stability and performance of electronic display materials.
• Polymer Modification: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and low surface energy properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed coupling reactions to build complex molecules.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	4-Bromo-2,3,5,6-Tetrafluorotoluene
CAS No.	33564-68-0
Molecular Formula	C7H2BrF4
Molecular Weight	240.99 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-bromotoluene; 4-Bromo-2,3,5,6-tetrafluoro-1-methylbenzene; alpha,alpha,alpha,4-Tetrabromo-2,3,5,6-tetrafluorotoluene; Toluene, 4-bromo-2,3,5,6-tetrafluoro-; 1-Bromo-2,3,5,6-tetrafluoro-4-methylbenzene; 4-Methyl-2,3,5,6-tetrafluorobromobenzene
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2,3,5,6-tetrafluorotoluene is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards, and comprehensive analytical testing, including GC, HPLC, and NMR, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) documenting all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.