Description

Venturicidin is a potent, macrocyclic lactone antibiotic isolated from *Streptomyces* species. This compound is a crucial biochemical tool for studying oxidative phosphorylation and ATP synthesis, specifically as a highly selective inhibitor of the mitochondrial F0F1-ATP synthase. It is essential for researchers in life sciences, biochemistry, and pharmacology who require precise molecular probes for investigating cellular energy metabolism and mitochondrial function.

Application

• Biochemical Research: A primary tool for studying the mechanism and kinetics of ATP synthase (Complex V) in oxidative phosphorylation.
• Mitochondrial Function Analysis: Used to inhibit mitochondrial ATP production, enabling studies on cellular bioenergetics, apoptosis, and metabolic pathways.
• Antimicrobial Studies: Serves as a reference compound in research exploring the structure and function of bacterial F-type ATPases.
• Pharmacology & Toxicology: Employed in screening assays and mechanistic studies to understand the impact of energy metabolism disruption.
• Academic & Industrial R&D: A standard reagent in university and pharmaceutical R&D laboratories for fundamental and applied research in bioenergetics.

Basic Information

Product Name	Venturicidin
CAS No.	33538-72-6
Molecular Formula	C36H59NO10
Molecular Weight	665.86 g/mol
Synonyms	Venturicidin A; Antibiotic 73-1424; Antibiotic M 139603; NSC 163042; Venturicidin X; F0F1-ATPase inhibitor; Mitochondrial ATP synthase inhibitor; Antibiotic from *Streptomyces* sp.
EINECS	Contact for details

Quality Control

Our Venturicidin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance records.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Biological Activity	Inhibits mitochondrial F0F1-ATPase
Solubility	Soluble in DMSO, ethanol, methanol; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.