Description

Venturicidin A is a potent, naturally occurring antifungal antibiotic belonging to the oligomycin family. This compound is a crucial biochemical tool and research standard due to its specific inhibitory action on mitochondrial ATP synthase (F0F1-ATPase). It is primarily utilized in life science research for studying oxidative phosphorylation, mitochondrial function, and cellular bioenergetics. Researchers in biochemistry, pharmacology, and microbiology rely on this high-purity reference material for mechanistic studies and assay development.

Application

• Mitochondrial Research: A key inhibitor used to study the mechanism and kinetics of mitochondrial ATP synthase (Complex V) in oxidative phosphorylation.
• Bioenergetics & Metabolism Studies: Employed to investigate cellular energy production, metabolic pathways, and the role of ATP in various physiological and pathological processes.
• Antifungal Mechanism Research: Serves as a reference compound for studying the action of polyketide-derived antibiotics against fungal pathogens, particularly in agricultural and medical mycology.
• Biochemical Assay Standard: Used as a standard or control in enzymatic assays and high-throughput screening (HTS) platforms targeting mitochondrial function.
• Pharmacology & Toxicology: Applied in research exploring mitochondrial dysfunction as a factor in disease states and drug-induced toxicity.

Basic Information

Product Name	Venturicidin A
CAS No.	33538-71-5
Molecular Formula	C34H55NO9
Molecular Weight	621.81 g/mol
Synonyms	Venturicidin A; Antibiotic 63-1; Antibiotic M 139603; Antimycin A3 (related); Oligomycin B (structural analog); F0F1-ATPase inhibitor; Mitochondrial ATP synthase inhibitor; 3,9-Epoxy-4,8-dihydroxy-10-[(2R,4R,5S,6S)-4-hydroxy-5,6-dimethyl-2-(2-methylbutanoyloxy)oxan-2-yl]-3,4,5,6,7,8,9,10-octahydro-1H-2-benzoxacyclododecine-1,11(12H)-dione
EINECS	Contact for details

Quality Control

Our Venturicidin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent condensation. Keep the container sealed under an inert atmosphere when not in use to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on dried basis)
Loss on Drying	≤ 2.0%
Solubility	Soluble in DMSO, ethanol, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.