Description

4-(Trifluoromethyl)-1H-Imidazole is a versatile fluorinated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in the unique combination of the imidazole scaffold and the electron-withdrawing trifluoromethyl group, which imparts desirable properties to target molecules. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for N-heterocyclic carbene (NHC) ligands and other organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functional polymers, ionic liquids, and advanced organic electronic materials.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethylimidazole moiety into complex molecular architectures in medicinal and discovery chemistry.

Basic Information

Product Name	4-(Trifluoromethyl)-1H-Imidazole
CAS No.	33468-69-8
Molecular Formula	C4H3F3N2
Molecular Weight	136.08 g/mol
Synonyms	4-(Trifluoromethyl)imidazole; 4-Trifluoromethyl-1H-imidazole; 1H-Imidazole, 4-(trifluoromethyl)-; 4-Trifluoromethylimidazole; α,α,α-Trifluoro-1H-imidazole-4-methane; 4-CF3-Imidazole; 4-(Trifluoromethyl)glyoxaline
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-1H-Imidazole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.