Description

2-Hydroxy-5-Trifluoromethylpyridine is a high-value fluorinated pyridine derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, combining a hydroxyl group with a trifluoromethyl substituent, makes it an essential intermediate for creating compounds with enhanced biological activity and material properties. This product is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile building block for medicinal chemistry and process chemistry in both academic and industrial R&D settings.

Basic Information

Product Name	2-Hydroxy-5-Trifluoromethylpyridine
CAS No.	33252-63-0
Molecular Formula	C6H4F3NO
Molecular Weight	163.10 g/mol
Synonyms	5-(Trifluoromethyl)pyridin-2-ol; 2-Pyridinol, 5-(trifluoromethyl)-; 5-Trifluoromethyl-2-hydroxypyridine; 2-Hydroxy-5-(trifluoromethyl)pyridine; 5-Trifluoromethyl-2-pyridone; 2-Hydroxy-5-trifluoromethyl pyridine; 2(1H)-Pyridinone, 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-5-Trifluoromethylpyridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.