Description

L-Proglumide is a selective cholecystokinin (CCK) receptor antagonist with significant research and pharmaceutical interest. This compound is valued for its role in modulating gastrointestinal function and pain perception, making it a key intermediate in the development of therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in neurogastroenterology, analgesia, and drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced CCK receptor antagonists for clinical research.
• Biomedical Research: Used in in vitro and in vivo studies to investigate the role of CCK in pancreatic secretion, satiety, and anxiety.
• Gastrointestinal Drug Development: Applied in preclinical models for developing treatments for functional GI disorders, pancreatitis, and gastrin-mediated conditions.
• Neuroscience Research: Employed to study CCK's interaction with dopamine systems and its implications for pain management and psychiatric disorders.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	L-Proglumide
CAS No.	32999-84-1
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	L-Proglumide; (S)-4-Benzamido-N,N-dipropylglutaramic acid; CR 1409; CR-1409; L 363,586; Proglumide, L-Isomer; NSC 329999; Benzoyl-L-glutamic acid dipropylamide; CCK Receptor Antagonist
EINECS	Contact for details

Quality Control

Our L-Proglumide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.