Description

Isosorbide-5-Mononitrate-2-Glucuronide is a key glucuronide metabolite of the cardiovascular drug isosorbide mononitrate, which is widely used in the management of angina pectoris. This compound is of significant importance in pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies, as it helps in understanding the drug's clearance pathway and potential drug-drug interactions. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in bioanalytical method development, ADME (Absorption, Distribution, Metabolism, and Excretion) profiling, and the production of reference standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of isosorbide mononitrate and its metabolites in biological matrices.
• Metabolite Identification & Profiling: Critical for in vitro and in vivo ADME studies to map the metabolic fate of isosorbide mononitrate.
• Bioanalytical Method Development: Serves as a critical standard for developing and validating robust HPLC, LC-MS, or GC-MS methods for pharmacokinetic studies.
• Drug Impurity Testing: Used to identify and quantify related substances or degradation products in active pharmaceutical ingredient (API) batches.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential toxicity of drug metabolites.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., with FDA, EMA) to demonstrate comprehensive understanding of a drug's metabolism.

Basic Information

Product Name	Isosorbide-5-Mononitrate-2-Glucuronide
CAS No.	32871-20-8
Molecular Formula	C12H17NO11
Molecular Weight	351.26 g/mol
Synonyms	ISMN-2-Glucuronide; Isosorbide 5-mononitrate 2-O-β-D-glucuronide; 1,4:3,6-Dianhydro-D-glucitol 5-nitrate 2-O-β-D-glucopyranosiduronic acid; 2-O-(β-D-Glucopyranosyluronic acid)-1,4:3,6-dianhydro-5-O-nitro-D-glucitol; Isosorbide Mononitrate Glucuronide; ISMN Glucuronide Metabolite
EINECS	Contact for details

Quality Control

Our Isosorbide-5-Mononitrate-2-Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and reference standard applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the container to reach room temperature before opening to minimize moisture condensation. The material should be handled in a controlled environment to ensure integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.