Description

Mono-6-o-(p-Toluenesulfonyl)-α-Cyclodextrin is a key functionalized derivative of α-cyclodextrin, where a single primary hydroxyl group is selectively sulfonylated with a p-toluenesulfonyl (tosyl) group. This modification is critical for introducing a reactive handle, enabling the synthesis of more complex cyclodextrin-based architectures for advanced research and industrial applications. It is primarily utilized by pharmaceutical researchers, material scientists, and specialty chemical manufacturers developing novel drug delivery systems, separation media, and supramolecular catalysts.

Application

• Pharmaceutical Intermediate: Serves as a pivotal precursor for synthesizing mono-substituted α-cyclodextrin derivatives with amines, azides, or other functional groups for drug conjugation and targeted delivery systems.
• Chromatography Media: Used in the development of chiral stationary phases (CSPs) for high-performance liquid chromatography (HPLC) to separate enantiomers of pharmaceutical compounds.
• Supramolecular Chemistry: Acts as a building block for constructing molecular machines, sensors, and complex host-guest systems due to its defined single-point reactivity.
• Polymer Science: Employed to create cyclodextrin-based polymers, hydrogels, or dendrimers with tailored properties for encapsulation and controlled release.
• Chemical Biology Probes: Facilitates the creation of labeled cyclodextrins for studying biological recognition and membrane transport processes.
• Catalyst Development: Provides a platform for anchoring catalytic sites onto the cyclodextrin scaffold for asymmetric synthesis and green chemistry applications.

Basic Information

Product Name	Mono-6-o-(p-Toluenesulfonyl)-α-Cyclodextrin
CAS No.	32860-56-3
Molecular Formula	C49H74O37S
Molecular Weight	1239.15 g/mol
Synonyms	6-O-(p-Tolylsulfonyl)-α-cyclodextrin; 6-O-Tosyl-α-cyclodextrin; α-Cyclodextrin 6-mono-p-toluenesulfonate; Mono(6-O-p-toluenesulfonyl)-α-cyclodextrin; 6-Mono-O-tosyl-α-cyclodextrin; 6-O-(4-Methylbenzenesulfonyl)-α-cyclodextrin; 6-Ts-α-CD; α-CD-6-OTs
EINECS	Contact for details

Quality Control

Our Mono-6-o-(p-Toluenesulfonyl)-α-Cyclodextrin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and structural confirmation by NMR and MS, to ensure consistent quality and batch-to-batch reproducibility suitable for research and process development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.