Description

12-o-Tetradecanoylphorbol is a potent phorbol ester derivative, widely recognized for its role in biochemical and pharmacological research. This compound is a critical tool for studying protein kinase C (PKC) activation and related signal transduction pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in cancer research, cell biology studies, and the development of novel therapeutic agents.

Application

• Biomedical Research: As a potent activator of protein kinase C (PKC) isoforms for studying cell signaling, tumor promotion, and apoptosis.
• Cancer Research: Used in vitro to investigate tumorigenesis mechanisms and to screen for potential PKC inhibitors as anti-cancer drugs.
• Cell Biology Studies: Applied in experiments to examine cellular processes such as proliferation, differentiation, and immune response modulation.
• Pharmacology & Toxicology: Serves as a reference standard and a tool compound for studying the biological effects of phorbol esters.
• Biochemical Assay Development: Utilized in the development and validation of high-throughput screening assays targeting PKC activity.
• Academic Research: A key reagent in university and institutional labs for fundamental research in molecular biology and biochemistry.

Basic Information

Product Name	12-o-Tetradecanoylphorbol
CAS No.	32752-30-0
Molecular Formula	C36H56O8
Molecular Weight	616.83 g/mol
Synonyms	12-O-Tetradecanoylphorbol 13-Acetate; TPA; Phorbol 12-Myristate 13-Acetate; PMA; Tetradecanoylphorbol Acetate; NSC 350836; 12-Tetradecanoylphorbol-13-acetate; 12-O-Tetradecanoylphorbol-13-acetate
EINECS	251-215-8

Quality Control

Our 12-o-Tetradecanoylphorbol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We ensure compliance with relevant standards for research-grade chemicals, supporting the integrity of your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, ethanol, acetone; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.