Description

Phorbol 13-Acetate CAS NO 32752-29-7 is a biologically active phorbol ester derivative, widely recognized as a potent activator of protein kinase C (PKC). This compound is a critical research tool for studying signal transduction pathways, cellular proliferation, and tumor promotion mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology, immunology, and cell biology.

Application

• Biomedical Research: As a standard PKC activator in cell signaling and signal transduction pathway studies.
• Oncology Research: Used to investigate tumor promotion mechanisms and study the role of PKC in cancer cell proliferation and apoptosis.
• Immunology Studies: Employed to examine the activation and regulation of immune cells, such as T-cells and macrophages.
• Pharmacology & Toxicology: Serves as a reference standard and tool compound for screening PKC inhibitors and evaluating drug efficacy.
• Cell Biology: Applied in studies of cellular differentiation, gene expression, and inflammatory responses.
• Biochemical Assay Development: Used as a critical reagent in developing and validating in vitro PKC activity assays.

Basic Information

Product Name	Phorbol 13-Acetate
CAS No.	32752-29-7
Molecular Formula	C24H32O8
Molecular Weight	448.51 g/mol
Synonyms	Phorbol 13-acetate; 12-O-Tetradecanoylphorbol-13-acetate (TPA) analog; 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 13-acetate; NSC 408023; Phorbol 13-monoacetate; 13-Acetylphorbol; 1,6-Dien-3-one, 4,9,12-beta,13-alpha,20-pentahydroxytiglia-, 13-acetate
EINECS	Contact for details

Quality Control

Our Phorbol 13-Acetate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (IR, NMR). We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.