Description

2-Propyne-1-Sulfonyl Chloride is a highly reactive organosulfur building block, primarily valued for its terminal alkyne and sulfonyl chloride functionalities. This dual reactivity makes it a critical intermediate for constructing complex molecular architectures in advanced synthetic chemistry. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and plant growth regulators with sulfonyl moiety activity.
• Click Chemistry Reagent: Serves as a bifunctional linker in Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and material surface functionalization.
• Polymer & Material Science: Monomer or cross-linking agent for producing specialty polymers with tailored thermal, mechanical, or surface properties.
• Ligand & Catalyst Development: Precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) to develop sulfonate-based probes for enzyme activity studies.

Basic Information

Product Name	2-Propyne-1-Sulfonyl Chloride
CAS No.	32623-88-4
Molecular Formula	C3H3ClO2S
Molecular Weight	138.57 g/mol
Synonyms	Propargylsulfonyl chloride; 3-(Chlorosulfonyl)-1-propyne; 1-Propyne-3-sulfonyl chloride; Prop-2-yn-1-sulfonyl chloride; HC≡CCH2SO2Cl; Propargyl sulfone chloride
EINECS	Contact for details

Quality Control

Our 2-Propyne-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for assay determination, to ensure it meets the high standards required for research and process chemistry. A Certificate of Analysis (COA) with detailed specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.