Description

2,3,4,6-Tetrakis-o-Trimethylsilyl-D-Gluconolactone is a key protected intermediate in organic synthesis, specifically a fully silylated derivative of D-gluconolactone. This compound matters because it provides a versatile, moisture-stable building block for the controlled introduction of carbohydrate moieties and chiral centers into complex molecules. It is primarily needed by research and development laboratories, as well as production facilities in the pharmaceutical and fine chemical industries, for applications in nucleoside chemistry, chiral ligand synthesis, and the development of bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a crucial protected synthon in the synthesis of novel nucleoside analogs and antiviral/anticancer agents.
• Chiral Auxiliary & Ligand Synthesis: Utilized for constructing chiral catalysts and ligands for asymmetric synthesis due to its defined stereochemistry.
• Carbohydrate Chemistry: Acts as a key starting material for the preparation of complex, selectively protected sugars and glycomimetics.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals requiring specific stereochemical configurations.
• Research & Development: Used in academic and industrial R&D for exploring new synthetic methodologies and bioactive molecule libraries.
• Material Science Precursor: Potential application in the synthesis of functionalized polymers and surfaces with carbohydrate-based recognition elements.

Basic Information

Product Name	2,3,4,6-Tetrakis-o-Trimethylsilyl-D-Gluconolactone
CAS No.	32384-65-9
Molecular Formula	C18H42O6Si4
Molecular Weight	466.88 g/mol
Synonyms	D-Gluconolactone, 2,3,4,6-tetrakis-O-(trimethylsilyl)-; Tetrakis(trimethylsilyl) D-gluconolactone; 2,3,4,6-Tetra-O-trimethylsilyl-D-glucono-1,5-lactone; TMS-Gluconolactone; Per-O-trimethylsilylated D-gluconolactone; (3R,4S,5S,6R)-3,4,5,6-Tetrakis(trimethylsilyloxy)tetrahydro-2H-pyran-2-one
EINECS	Contact for details

Quality Control

Our 2,3,4,6-Tetrakis-o-Trimethylsilyl-D-Gluconolactone undergoes rigorous quality testing to ensure compliance with industry standards. Each batch is characterized and controlled using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, chiral purity, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.