Description

4-Phenylbutyryl Hydroxamic Acid is a specialized hydroxamic acid derivative that serves as a potent and selective inhibitor of histone deacetylase (HDAC) enzymes. This compound matters for its critical role in epigenetic research and as a key intermediate in the development of targeted therapeutic agents. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on oncology, neurology, and inflammatory disease pathways.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) intermediate in the synthesis of novel HDAC inhibitors for cancer therapy.
• Biochemical Assay Development: Used as a potent enzymatic inhibitor to study HDAC activity, enzyme kinetics, and epigenetic mechanisms in cellular models.
• Preclinical Studies: Employed in in vitro and in vivo research to investigate the effects of HDAC inhibition on cell differentiation, proliferation, and apoptosis.
• Chemical Synthesis: Serves as a versatile building block for the preparation of more complex hydroxamate-based compounds with modified biological activity.
• Academic Research: A valuable tool compound for universities and research institutes exploring epigenetics, gene expression regulation, and signal transduction pathways.

Basic Information

Product Name	4-Phenylbutyryl Hydroxamic Acid
CAS No.	32153-46-1
Molecular Formula	C10H13NO2
Molecular Weight	179.22 g/mol
Synonyms	4-Phenylbutyrohydroxamic Acid; 4-Phenylbutanohydroxamic Acid; N-Hydroxy-4-phenylbutyramide; PBA-HA; HDAC Inhibitor (Phenylbutyrate Hydroxamate); 4-Phenylbutyric Hydroxamic Acid; 4-PBHA; 4-Phenylbutyrylhydroxamic Acid
EINECS	Contact for details

Quality Control

Our 4-Phenylbutyryl Hydroxamic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical production, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere); therefore, containers should be kept sealed under an inert atmosphere such as nitrogen or argon when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118°C - 122°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.