Description

3,4-Difluorobenzotrifluoride is a versatile fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by R&D and production chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and CNS-targeted drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the difluorobenzotrifluoride moiety enhances biological activity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Functional Material Precursor: Employed in creating specialty polymers, coatings, and electronic chemicals that require high thermal and chemical stability.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial research exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Item	Details
Product Name	3,4-Difluorobenzotrifluoride
CAS No.	32137-19-2
Molecular Formula	C7H3F5
Molecular Weight	182.09 g/mol
Synonyms	1,2-Difluoro-4-(trifluoromethyl)benzene; 3,4-Difluoro-α,α,α-trifluorotoluene; 3,4-Difluoro(trifluoromethyl)benzene; 4-(Trifluoromethyl)-1,2-difluorobenzene; Benzene, 1,2-difluoro-4-(trifluoromethyl)-; 3,4-DFBTF
EINECS	Contact for details

Quality Control

Our 3,4-Difluorobenzotrifluoride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.45 g/mL
Boiling Point	~142-144 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.