Description

Serine Hydroxamate CAS NO 31697-35-5 is a hydroxamic acid derivative of the amino acid serine, functioning as a potent and specific inhibitor of glutamine synthetase. This compound is a critical research tool for studying nitrogen metabolism, cellular signaling, and enzyme kinetics in biological systems. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and agricultural biotechnology sectors.

Application

• Biochemical Research: As a selective inhibitor of glutamine synthetase (GS) for studying nitrogen assimilation, ammonia detoxification, and glutamine-dependent pathways in cell culture and in vitro assays.
• Pharmaceutical Development: Investigation of potential therapeutic applications targeting glutamine metabolism in areas such as oncology, neurology, and metabolic disorders.
• Agricultural Science: Research into plant physiology and the development of compounds that may modulate nitrogen use efficiency or act as herbicides by targeting plant glutamine synthetase.
• Enzyme Studies: Used in enzymology to probe the active site and mechanism of glutamine synthetase, aiding in structural biology and drug design efforts.
• Microbiology: Study of bacterial and fungal nitrogen metabolism, with applications in understanding microbial physiology and identifying novel antimicrobial targets.

Basic Information

Product Name	Serine Hydroxamate
CAS No.	31697-35-5
Molecular Formula	C3H8N2O4
Molecular Weight	136.11 g/mol
Synonyms	L-Serine hydroxamate; Serine Hydroxamic Acid; O-Hydroxyamino-L-serine; L-Serine, O-(hydroxyamino)-; (2S)-2-Amino-3-(hydroxyamino)-3-oxopropanoic acid; GS Inhibitor; Glutamine Synthetase Inhibitor; NSC 112697
EINECS	Contact for details

Quality Control

Our Serine Hydroxamate is manufactured under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is analyzed using validated methods including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.