Description

11-Desacetoxywortmannin is a potent and selective inhibitor of phosphatidylinositol 3-kinase (PI3K), a key enzyme in cellular signaling pathways. This compound is a critical research tool for studying the role of PI3K in cell growth, proliferation, and survival, with significant implications for oncology and metabolic disease research. It is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on signal transduction and drug discovery.

Application

• Biochemical Research: A key tool compound for selectively inhibiting PI3K activity in in vitro enzyme assays and cell-based studies.
• Oncology Research: Used to investigate the PI3K/Akt/mTOR signaling pathway's role in cancer cell proliferation, survival, and resistance to therapy.
• Metabolic Disease Studies: Applied in research exploring insulin signaling, glucose metabolism, and related disorders.
• Cell Biology: Utilized to dissect cellular processes such as autophagy, apoptosis, and vesicular trafficking where PI3K is involved.
• Drug Discovery & Development: Serves as a reference standard and a pharmacological probe for validating assays and screening novel therapeutic candidates targeting the PI3K pathway.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in molecular biology and pharmacology.

Basic Information

Item	Details
Product Name	11-Desacetoxywortmannin
CAS No.	31652-69-4
Molecular Formula	C23H24O8
Molecular Weight	428.43 g/mol
Synonyms	11-Desacetoxy Wortmannin; 11-Deacetoxywortmannin; 11-Desacetoxy-wortmannin; (3S,3aR,5S,5aR,8aR,9bS)-3,8a-Dihydroxy-3a,5a,9-trimethyl-3,3a,4,5,5a,6,7,8,8a,9b-decahydro-5,9a-methanoazuleno[4,5-b]furan-2,8-dione; PI3 Kinase Inhibitor (11-Desacetoxywortmannin)
EINECS	Contact for details

Quality Control

Our 11-Desacetoxywortmannin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.