Description

(3α)-Allopregnanolone 3-β-D-Glucuronide CAS NO 31300-86-4 is a conjugated metabolite of the endogenous neurosteroid allopregnanolone, formed via glucuronidation. This compound is of significant value as a critical reference standard and analytical tool in pharmaceutical research and clinical diagnostics. It is primarily needed by research institutions, pharmaceutical companies, and diagnostic laboratories for studying neurosteroid metabolism, pharmacokinetics, and developing bioanalytical assays.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of allopregnanolone metabolites in drug development and bioequivalence studies.
• Clinical Research & Diagnostics: Serves as a calibrator or control in LC-MS/MS methods for accurately measuring allopregnanolone-glucuronide levels in human plasma, serum, or urine for endocrine and neurological research.
• Metabolite Identification & Profiling: Essential for in vitro and in vivo studies aimed at identifying and quantifying phase II metabolites of neuroactive steroids.
• Biomarker Development: Employed in research to investigate the role of neurosteroid conjugates as potential biomarkers for conditions like premenstrual dysphoric disorder (PMDD), postpartum depression, and stress-related disorders.
• Enzyme Activity Assays: Used as a specific substrate to study the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in steroid hormone metabolism.

Basic Information

Product Name	(3α)-Allopregnanolone 3-β-D-Glucuronide
CAS No.	31300-86-4
Molecular Formula	C27H42O9
Molecular Weight	510.62 g/mol
Synonyms	Allopregnanolone 3β-D-Glucuronide; 3α-Hydroxy-5α-pregnan-20-one 3β-D-Glucuronide; 5α-Pregnan-3α-ol-20-one 3β-D-Glucuronide; Allopregnanolone Glucuronide; Pregnanolone Glucuronide; 3α,5α-Tetrahydroprogesterone 3β-D-Glucuronide; THP-Glucuronide; (3α,5α)-3-Hydroxypregnan-20-one 3β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our high-purity reference standards are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and LC-MS for structural confirmation, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, containing batch-specific data on purity, impurities, and analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation. The material is intended for laboratory use only.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.