Description

5-(Trifluoromethoxy)Pyridine-2-Carbaldehyde is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a trifluoromethoxy group and an aldehyde functionality, makes it indispensable for creating novel compounds with enhanced biological activity and material properties. This intermediate is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve metabolic stability and lipophilicity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and fluorescent tags for biochemical research and diagnostic applications.

Basic Information

Product Name	5-(Trifluoromethoxy)Pyridine-2-Carbaldehyde
CAS No.	31191-05-6
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	2-Formyl-5-(trifluoromethoxy)pyridine; 5-(Trifluoromethoxy)-2-pyridinecarboxaldehyde; 2-Pyridinecarboxaldehyde, 5-(trifluoromethoxy)-; 5-Trifluoromethoxypicolinaldehyde; 5-(Trifluoromethoxy)picolinaldehyde; 5-(Trifluoromethoxy)-2-formylpyridine; 31191-05-6
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethoxy)Pyridine-2-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.