Description

5-Fluoro-2-Formylpyridine is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a formyl group and a fluorine atom on the pyridine ring, makes it an indispensable precursor for constructing complex heterocyclic compounds and active pharmaceutical ingredients (APIs). This high-purity intermediate is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and material science industries seeking to introduce fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, organic semiconductors, and liquid crystals for electronic applications.
• Chemical Biology Probes: Utilized to create fluorinated probes and tags for studying biological processes and protein interactions.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to build complex biaryl systems.

Basic Information

Product Name	5-Fluoro-2-Formylpyridine
CAS No.	31181-88-1
Molecular Formula	C6H4FNO
Molecular Weight	125.10 g/mol
Synonyms	2-Formyl-5-fluoropyridine; 5-Fluoropyridine-2-carboxaldehyde; 5-Fluoro-2-pyridinecarboxaldehyde; 5-Fluoropicolinaldehyde; 2-Pyridinecarboxaldehyde, 5-fluoro-; 5-Fluoropyridine-2-carbaldehyde
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Formylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.