Description

5-Fluoro-2-Methylpyridine is a versatile fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic introduction of fluorine and methyl groups onto the pyridine ring, enabling precise modulation of the electronic and steric properties of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, CNS agents, and anti-infective drugs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials.
• Chemical Biology Probes: Useful for synthesizing fluorinated analogs of bioactive molecules for metabolic and mechanistic studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high-quality fluorinated heterocycles.

Basic Information

Product Name	5-Fluoro-2-Methylpyridine
CAS No.	31181-53-0
Molecular Formula	C6H6FN
Molecular Weight	111.12 g/mol
Synonyms	2-Methyl-5-fluoropyridine; 5-Fluoro-2-picoline; 5-Fluoro-2-methylpyridine; 2-Picoline, 5-fluoro-; 5-Fluoro-2-methyl-pyridine; 5-Fluoro-2-methylpyridine (2-Methyl-5-fluoropyridine)
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methylpyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider maintaining under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.