Description

5-(Bromomethyl)-2-Fluoropyridine Hydrobromide is a high-purity, bifunctional organic building block essential for advanced chemical synthesis. This compound is valued for its dual reactive sites, enabling its use as a versatile intermediate in the creation of complex molecular architectures. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging the fluoropyridine moiety for bioactivity.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and functional polymers.
• Cross-Coupling Reactions: The bromomethyl group makes it a suitable substrate for various palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings.
• Derivatization Agent: Used to introduce fluoropyridine motifs into larger molecules for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	5-(Bromomethyl)-2-Fluoropyridine Hydrobromide
CAS No.	31140-61-1
Molecular Formula	C6H6Br2FN
Molecular Weight	278.93 g/mol
Synonyms	2-Fluoro-5-(bromomethyl)pyridine hydrobromide; 5-(Bromomethyl)-2-fluoropyridine HBr; 2-Fluoro-5-bromomethylpyridine Hydrobromide; 5-Bromomethyl-2-fluoropyridine Hydrobromide; (2-Fluoro-5-pyridinyl)methyl bromide hydrobromide; 2-Fluoro-5-(bromomethyl)pyridine, hydrobromide; Pyridine, 5-(bromomethyl)-2-fluoro-, hydrobromide
EINECS	Contact for details

Quality Control

Every batch of 5-(Bromomethyl)-2-Fluoropyridine Hydrobromide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Single Unknown Impurity	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.