Description

8-Fluoro-4-Hydroxy-2-(Trifluoromethyl)Quinoline is a high-value, multi-functional heterocyclic building block distinguished by its unique trifluoromethyl and fluoro substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its fluorine-containing motifs enhance biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate sophisticated fluorinated quinoline scaffolds into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory research.
• Agrochemical Synthesis: Serves as a precursor for creating new-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profile.
• Material Science Research: Used in the development of organic electronic materials, such as OLED emitters or charge-transport layers, due to the electron-withdrawing nature of the fluorinated groups.
• Chemical Biology & Probe Development: Employed as a scaffold for designing fluorescent probes or enzyme inhibitors used in biochemical assays and diagnostic tools.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	8-Fluoro-4-Hydroxy-2-(Trifluoromethyl)Quinoline
CAS No.	31009-31-1
Molecular Formula	C10H5F4NO
Molecular Weight	231.15 g/mol
Synonyms	8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline; 2-(Trifluoromethyl)-8-fluoro-4-quinolinol; 8-Fluoro-2-(trifluoromethyl)-4-quinolinol; 4-Hydroxy-8-fluoro-2-trifluoromethylquinoline; 31009-31-1; 8-Fluoro-4-hydroxy-2-trifluoromethylquinoline; 4-Quinolinol, 8-fluoro-2-(trifluoromethyl)-; 8-Fluoro-2-trifluoromethylquinolin-4-ol
EINECS	Contact for details

Quality Control

Our 8-Fluoro-4-Hydroxy-2-(Trifluoromethyl)Quinoline is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.