Description

4-Fluoro-2-Methylphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic synthesis. Its value lies in its ability to introduce the versatile 4-fluoro-2-methylphenyl moiety into target molecules, enabling the creation of advanced intermediates with specific structural and electronic properties. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Compound Development: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorine atom and methyl group modulate biological activity and environmental persistence.
• Liquid Crystal & OLED Material Production: Serves as a precursor for creating fluorinated aromatic cores in advanced electronic and display materials, improving their performance characteristics.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions (e.g., Kumada coupling) to efficiently form biaryl structures, a common motif in many functional molecules.
• Nucleophilic Addition to Carbonyls: Reacts with aldehydes, ketones, esters, and carbon dioxide to produce secondary/tertiary alcohols and carboxylic acids with the incorporated aryl group.
• Fine Chemical & Specialty Polymer Manufacturing: Facilitates the production of custom fluorinated monomers and specialty chemicals for high-value applications.

Basic Information

Product Name	4-Fluoro-2-Methylphenylmagnesium Bromide
CAS No.	30897-90-6
Molecular Formula	C7H6FMgBr
Molecular Weight	213.33 g/mol
Synonyms	2-Methyl-4-fluorophenylmagnesium bromide; (4-Fluoro-2-methylphenyl)magnesium bromide; 4-Fluoro-o-tolylmagnesium bromide; Magnesium, bromo(4-fluoro-2-methylphenyl)-; Grignard Reagent (4-Fluoro-2-methylphenyl); 4-Fluoro-2-methylphenyl magnesium bromide solution; p-Fluoro-o-tolylmagnesium bromide
EINECS	Contact for details

Quality Control

Every batch of our 4-Fluoro-2-Methylphenylmagnesium Bromide is manufactured and handled under stringent quality protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration, titration assay, and impurity profile. Our quality system is designed to support cGMP development and production, ensuring the material meets the exacting standards required for pharmaceutical and advanced chemical applications.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and highly volatile. It must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions, or as specified on the label. Keep the container tightly sealed in a cool, dry, well-ventilated place, away from incompatible materials such as acids, water, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light brown
Concentration (in THF or Ether)	0.5 M - 2.0 M (Customizable)
Assay (Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.