Description

2,5-Dimethylphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis. Its core value proposition lies in its ability to act as a powerful nucleophile and carbon nucleophile source for the formation of new carbon-carbon bonds, a fundamental transformation in constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it is employed to introduce the 2,5-dimethylphenyl moiety into target molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring aryl group functionalization.
• Agrochemical Production: Used in the synthesis of herbicides, fungicides, and insecticides that incorporate substituted phenyl groups for enhanced efficacy.
• Fine Chemical and Specialty Chemical Manufacturing: Employed in the production of dyes, pigments, liquid crystals, and other performance chemicals.
• Academic and R&D Laboratories: A fundamental reagent for methodological development in organic chemistry and for synthesizing novel compounds for material science research.
• Cross-Coupling Reactions: Serves as a coupling partner in various metal-catalyzed reactions, such as Kumada coupling, to form biaryl structures.
• Nucleophilic Addition to Carbonyls: Reacts with aldehydes, ketones, esters, and carbon dioxide to produce secondary/tertiary alcohols and carboxylic acids.

Basic Information

Product Name	2,5-Dimethylphenylmagnesium Bromide
CAS No.	30897-86-0
Molecular Formula	C8H9BrMg
Molecular Weight	209.37 g/mol
Synonyms	2,5-Dimethylphenylmagnesium bromide solution; (2,5-Dimethylphenyl)magnesium bromide; 1,4-Dimethyl-2-magnesio-benzene bromide; Magnesane, bromo(2,5-dimethylphenyl)-; Grignard reagent, 2,5-xylylmagnesium bromide; 2,5-Xylylmagnesium bromide; p-Xylylmagnesium bromide (ambiguous)
EINECS	Contact for details

Quality Control

Our 2,5-Dimethylphenylmagnesium Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as concentration (typically supplied as a solution in THF or diethyl ether), assay by titration, and impurity profile. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile, hygroscopic (moisture-sensitive), and easily oxidized (store under inert atmosphere) nature, this product must be stored under a dry, inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for extended stability. Handle and store away from moisture, air, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to light brown solution
Concentration (in THF)	0.5 M, 1.0 M, or 2.0 M (Custom concentrations available)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.