Description

4-(2-Aminoethyl)Benzenesulfonylfluoride Hydrochloride is a specialized chemical building block and protease inhibitor, primarily recognized for its role as the precursor to the serine protease inhibitor AEBSF. This compound matters for its ability to provide a stable, crystalline hydrochloride salt form, offering improved handling and storage characteristics for research and manufacturing. It is needed by pharmaceutical R&D teams, biochemical researchers, and fine chemical manufacturers engaged in proteomics, enzyme inhibition studies, and the synthesis of advanced pharmaceutical intermediates.

Application

• Protease Inhibition Research: Serves as a key precursor for the synthesis of 4-(2-Aminoethyl)benzenesulfonyl fluoride (AEBSF), a water-soluble, irreversible serine protease inhibitor used in cell biology and biochemistry.
• Pharmaceutical Intermediate: Utilized in the synthesis of more complex molecules targeting various disease pathways, particularly where sulfonyl fluoride chemistry is applicable.
• Bioconjugation & Probe Development: Acts as a starting material for creating activity-based probes (ABPs) to study enzyme function and activity in complex biological systems.
• Peptide & Protein Chemistry: Employed in modifying peptides or proteins to study structure-function relationships or to create novel bioconjugates.
• Chemical Biology Tool Compound: Used in high-throughput screening and target identification/validation within drug discovery pipelines.
• Fine Chemical Synthesis: Functions as a versatile building block in organic synthesis for introducing the 2-aminoethylbenzenesulfonyl moiety.

Basic Information

Product Name	4-(2-Aminoethyl)Benzenesulfonylfluoride Hydrochloride
CAS No.	30827-99-7
Molecular Formula	C8H10FNO2S • HCl
Molecular Weight	247.69 g/mol (Free base: 203.23 g/mol)
Synonyms	AEBSF Hydrochloride; 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride; 2-(4-Fluorosulfonylphenyl)ethylamine hydrochloride; p-(2-Aminoethyl)benzenesulfonyl fluoride HCl; AEBSF HCl; (4-(2-Aminoethyl)phenyl)sulfonyl fluoride hydrochloride; Pefabloc® SC precursor hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(2-Aminoethyl)Benzenesulfonylfluoride Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and safety parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.