Description

Geldanamycin is a naturally occurring benzoquinone ansamycin antibiotic that functions as a potent and specific inhibitor of the Hsp90 molecular chaperone. This mechanism of action makes it a critical research tool for studying protein folding, cellular stress response, and oncogenic signaling pathways. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery, cancer research, and the development of novel Hsp90-targeted therapeutics.

Application

• Biomedical Research: A fundamental tool for investigating the role of Hsp90 in protein homeostasis, cell signaling, and disease mechanisms, particularly in oncology.
• Drug Discovery & Development: Serves as a reference compound and a lead structure for the design and synthesis of novel Hsp90 inhibitors for potential cancer therapies.
• Cancer Research: Used in in vitro and in vivo studies to induce degradation of Hsp90 client proteins, leading to apoptosis in various cancer cell lines.
• Neurodegenerative Disease Studies: Applied in research models to explore the modulation of protein aggregation associated with conditions like Alzheimer's and Parkinson's disease.
• Signal Transduction Analysis: Employed to dissect complex signaling pathways that rely on Hsp90 for the stability and function of key kinases and transcription factors.
• Antibiotic Research: Studied for its inherent antimicrobial properties and its potential role in combating antibiotic-resistant bacterial strains.

Basic Information

Product Name	Geldanamycin
CAS No.	30562-34-6
Molecular Formula	C₂₉H₄₀N₂O₉
Molecular Weight	560.64 g/mol
Synonyms	Antibiotic M 344; Antibiotic U-5952; NSC 122750; 17-Demethoxy-17-amino-geldanamycin precursor; 19-(Aminomethyl)geldanamycin; Benzoquinone ansamycin antibiotic; Hsp90 Inhibitor I
EINECS	Contact for details

Quality Control

Our Geldanamycin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade chemicals to guarantee reliable and reproducible results in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.