Description

Phorbol, 20-Oxo-20-Deoxy 12-Myristate 13-Acetate, 4Beta is a potent, semi-synthetic derivative of the natural phorbol ester family, specifically engineered for advanced biochemical and pharmacological research. This compound is a critical tool for studying protein kinase C (PKC) signaling pathways, cellular proliferation, and tumor promotion mechanisms. It is essential for researchers and developers in pharmaceutical discovery, oncology research, and molecular biology who require high-purity, well-characterized biochemical probes.

Application

• Biochemical Research: A primary tool for the activation and study of Protein Kinase C (PKC) isoforms in cell signaling experiments.
• Oncology & Cancer Research: Used to investigate tumor promotion mechanisms, study cell transformation, and screen for potential chemopreventive agents.
• Pharmacology & Drug Discovery: Serves as a reference standard and active agent in assays designed to identify and validate PKC inhibitors or modulators.
• Cell Biology Studies: Employed to induce specific cellular responses, such as inflammation or proliferation, in model systems to understand underlying biological processes.
• Toxicology & Safety Assessment: Utilized as a positive control in studies assessing the tumor-promoting potential of other substances.
• Academic Research: Fundamental reagent for universities and research institutes exploring signal transduction, cell cycle regulation, and carcinogenesis.

Basic Information

Product Name	Phorbol, 20-Oxo-20-Deoxy 12-Myristate 13-Acetate, 4Beta
CAS No.	30358-69-1
Molecular Formula	C36H56O8
Molecular Weight	616.83 g/mol
Synonyms	4β-Phorbol 12-myristate 13-acetate 20-oxo-20-deoxy; 20-Oxo-20-deoxyphorbol 12-myristate 13-acetate; 4β-PMA 20-oxo-20-deoxy; 20-Deoxy-20-oxophorbol 12-tetradecanoate 13-acetate; PMA derivative; 12-O-Tetradecanoylphorbol-13-acetate 20-oxo-20-deoxy analog; TPA 20-oxo-20-deoxy; Phorbol myristate acetate oxo-deoxy derivative
EINECS	Contact for details

Quality Control

Our Phorbol, 20-Oxo-20-Deoxy 12-Myristate 13-Acetate, 4Beta is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.