Description

Ingenol CAS NO 30220-46-3 is a naturally occurring diterpenoid ester with significant biological activity. This compound is of high commercial and research interest due to its potent protein kinase C (PKC) modulating properties, which drive its utility in pharmaceutical development. It is primarily sought by the pharmaceutical, biotechnology, and advanced life science research sectors for applications in drug discovery and development.

Application

• Pharmaceutical Active Ingredient (API) Development: As a key intermediate or active component in the research and formulation of novel therapeutics.
• Oncology Research: Investigation of its pro-apoptotic and anti-proliferative effects for potential cancer treatments.
• Dermatological Applications: Used in research for developing treatments for skin conditions, leveraging its cell-modulating activity.
• Biochemical Research: Serves as a critical tool compound for studying PKC signaling pathways and cellular mechanisms.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related products.
• Preclinical Studies: Employed in animal models to evaluate pharmacokinetics, efficacy, and safety profiles.

Basic Information

Product Name	Ingenol
CAS No.	30220-46-3
Molecular Formula	C20H28O5
Molecular Weight	348.44 g/mol
Synonyms	Ingenol; Ingenol-3-angelate; PEP005; Ingenol Mebutate; (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a,6,9,10,10a-Hexahydro-1a,2,5,8a-tetrahydroxy-9-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl 2-methylbut-2-enoate
EINECS	Contact for details

Quality Control

Our Ingenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.