Description

4-Fluoro-1H-Imidazole is a versatile fluorinated heterocyclic building block of significant importance in modern synthetic chemistry. Its core value lies in the strategic introduction of a fluorine atom onto the imidazole scaffold, enabling precise modulation of electronic properties, lipophilicity, and metabolic stability in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a building block for creating specialized N-heterocyclic carbene (NHC) ligands and other organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated ionic liquids, conductive polymers, and other advanced functional materials.
• Chemical Biology Probes: Utilized to create fluorinated analogs of biomolecules for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for fine chemical suppliers and CDMOs serving the global life sciences market.

Basic Information

Item	Detail
Product Name	4-Fluoro-1H-Imidazole
CAS No.	30086-17-0
Molecular Formula	C3H3FN2
Molecular Weight	86.07 g/mol
Synonyms	4-Fluoroimidazole; 4-Fluoro-1H-imidazole; 1H-Imidazole, 4-fluoro-; 4-Fluorimidazole; 4-F-Imidazole; 4-Fluoro-1H-1,3-diazole; 4-Fluor-1H-imidazol
EINECS	Contact for details

Quality Control

Our 4-Fluoro-1H-Imidazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive and should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.