Description

3-Aminobenzenesulfonyl Fluoride Hydrochloride is a key aromatic sulfonyl fluoride derivative, serving as a versatile and reactive building block in advanced chemical synthesis. Its primary value lies in the sulfonyl fluoride (SO2F) group, which acts as a specific and stable warhead for covalent inhibitor development and click chemistry applications. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for creating protease inhibitors, activity-based probes, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of covalent drug candidates, especially serine protease inhibitors.
• Chemical Biology & Proteomics: Used to create activity-based probes (ABPs) for labeling and studying enzyme activity in complex biological systems.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides and pesticides with specific modes of action.
• Material Science: Employed in the surface functionalization of polymers and materials via sulfonyl fluoride-mediated coupling reactions.
• Bioconjugation: Facilitates the stable attachment of molecules to proteins, antibodies, or other biomolecules under physiological conditions.
• Research & Development: A valuable tool for medicinal chemistry and discovery chemistry programs focused on targeted covalent inhibition.

Basic Information

Product Name	3-Aminobenzenesulfonyl Fluoride Hydrochloride
CAS No.	3887-48-7
Molecular Formula	C6H7FNO2S·HCl
Molecular Weight	211.65 g/mol (Free base: 175.19 g/mol)
Synonyms	3-Aminobenzenesulfonyl fluoride HCl; m-Aminobenzenesulfonyl fluoride hydrochloride; Benzenesulfonyl fluoride, 3-amino-, hydrochloride; 3-Amino-phenylsulfonyl fluoride hydrochloride; 3-Aminophenylsulfonyl fluoride HCl; 3-Sulfamoylfluorobenzene hydrochloride; Meta-aminobenzenesulfonyl fluoride hydrochloride; AN-322/40238052
EINECS	Contact for details

Quality Control

Our 3-Aminobenzenesulfonyl Fluoride Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production use. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.