Description

2,3-Difluorotoluene CAS NO 3828-49-7 is a versatile fluorinated aromatic building block, prized for its unique electronic and steric properties introduced by the fluorine substituents. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs) where precise molecular tuning is required. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries for developing new compounds with enhanced stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in fluorinated analogs that improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties.
• Polymer Modification: Employed to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and lowering surface energy for coatings.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to create complex, multi-fluorinated aromatic systems.
• Solvent for Specialty Reactions: Acts as a solvent in specific fluorination reactions and other processes requiring a stable, moderately polar aromatic medium.

Basic Information

Product Name	2,3-Difluorotoluene
CAS No.	3828-49-7
Molecular Formula	C7H6F2
Molecular Weight	128.12 g/mol
Synonyms	1,2-Difluoro-3-methylbenzene; 3-Methyl-1,2-difluorobenzene; 2,3-Difluoro-1-methylbenzene; o,m-Difluorotoluene; Toluene, 2,3-difluoro-; 2,3-Difluoromethylbenzene; 2,3-Difluorophenylmethane
EINECS	223-327-6

Quality Control

Our 2,3-Difluorotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C (59°F and 77°F). Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Density (at 20°C)	1.15 - 1.18 g/mL
Refractive Index (n20D)	1.460 - 1.470

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.