Description

3-Trifluoromethylpyridine is a versatile fluorinated heterocyclic building block of significant industrial importance. Its unique structure, featuring a pyridine ring substituted with a strongly electron-withdrawing trifluoromethyl group, makes it a critical intermediate for synthesizing advanced molecules. This compound is essential for manufacturers in the agrochemical and pharmaceutical sectors seeking to enhance the biological activity and metabolic stability of their products. Its high volatility necessitates careful handling during processing and storage.

Application

• Agrochemical Intermediates: A key precursor for the synthesis of modern pesticides, herbicides, and fungicides, where the trifluoromethyl group improves lipophilicity and target binding.
• Pharmaceutical Building Blocks: Used in the research and development of active pharmaceutical ingredients (APIs), particularly in candidates for central nervous system (CNS) and anti-infective therapies.
• Ligand Synthesis for Catalysis: Serves as a starting material for creating sophisticated ligands used in transition metal catalysis, enabling novel synthetic transformations.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and electronic chemicals, due to its unique electronic properties.
• Fine Chemical Synthesis: Acts as a fluorinated synthon in multi-step organic synthesis to introduce the valuable CF3-pyridine moiety into complex molecules.

Basic Information

Product Name	3-Trifluoromethylpyridine
CAS No.	3796-23-4
Molecular Formula	C6H4F3N
Molecular Weight	147.10 g/mol
Synonyms	3-(Trifluoromethyl)pyridine; α,α,α-Trifluoro-3-picoline; 3-Pyridyltrifluoromethane; 3-CF3-Pyridine; Pyridine, 3-(trifluoromethyl)-; m-Trifluoromethylpyridine; 3-Trifluoromethylpyridine; 3-TFM-Pyridine
EINECS	223-269-8

Quality Control

Our 3-Trifluoromethylpyridine is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to verify identity and quantify impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent loss and maintain purity. Recommended long-term storage temperature is 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density	1.30 - 1.35 g/mL @ 20°C
Refractive Index	1.420 - 1.430 @ 20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.