Description

Norbutorphanol is a synthetic opioid compound of significant interest in pharmaceutical research and development. Its unique pharmacological profile makes it a valuable intermediate for exploring new therapeutic pathways and developing novel analgesic agents. This high-purity compound is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in advanced drug discovery and synthesis programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced opioid receptor ligands and potential analgesic drugs.
• Neuroscience Research: Used in preclinical studies to investigate opioid receptor (MOR, KOR, DOR) binding, activation, and signaling mechanisms.
• Analgesic Development: Acts as a key precursor or reference standard in R&D programs aimed at creating new pain management therapies with improved efficacy and safety profiles.
• Metabolic Studies: Employed as a substrate in studies investigating the metabolic pathways and pharmacokinetics of opioid-class compounds.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical substances.
• Chemical Synthesis: Functions as a versatile chiral synthon for organic chemists developing complex molecular architectures with specific stereochemistry.

Basic Information

Product Name	Norbutorphanol
CAS No.	3792-68-5
Molecular Formula	C21H29NO2
Molecular Weight	327.47 g/mol
Synonyms	17-(Cyclobutylmethyl)morphinan-3,14-diol; (-)-17-(Cyclobutylmethyl)morphinan-3,14-diol; Levonorbutorphanol; Norbutorphanol Tartrate; UNII-3B2Q8T4YVQ; 3B2Q8T4YVQ; (-)-Norbutorphanol; Norbutorphanol (base)
EINECS	Contact for details

Quality Control

Our Norbutorphanol CAS NO 3792-68-5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.