Description

Zebularine CAS NO 3690-10-6 is a potent and stable cytidine analog that functions as a DNA methyltransferase (DNMT) inhibitor. This compound is a critical research tool for epigenetic studies, enabling the investigation of DNA methylation's role in gene expression, cellular differentiation, and disease progression. It is primarily utilized by researchers and developers in the fields of pharmaceutical R&D, oncology research, and molecular biology.

Application

• Epigenetics Research: A foundational tool for studying DNA demethylation and gene reactivation in cellular models.
• Oncology and Cancer Biology: Investigated for its potential to reverse hypermethylation of tumor suppressor genes in cancer cell lines.
• Biochemical Assay Development: Used as a reference standard and active component in high-throughput screening assays for DNMT activity.
• Stem Cell Research: Applied in studies aimed at modulating cellular plasticity and differentiation pathways.
• Neurodegenerative Disease Research: Explored for its effects on epigenetic regulation in models of neurological disorders.
• Agricultural Biotechnology: Research into epigenetic modifications in plants for trait development and stress response.

Basic Information

Product Name	Zebularine
CAS No.	3690-10-6
Molecular Formula	C9H12N2O5
Molecular Weight	228.20 g/mol
Synonyms	1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one; 1-(β-D-Ribofuranosyl)dihydropyrimidin-2(1H)-one; 1-(β-D-Ribofuranosyl)-1,2-dihydro-2-pyrimidinone; 4-Amino-1-β-D-ribofuranosyl-1,2-dihydro-2-pyrimidinone; NSC 309132; 1-(β-D-Ribofuranosyl)-2(1H)-pyrimidinone
EINECS	223-010-4

Quality Control

Our Zebularine is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.