Description

2,3,4,5-Tetrafluoropyridine is a highly fluorinated heterocyclic building block of significant importance in advanced chemical synthesis. Its unique structure, featuring four fluorine atoms on the pyridine ring, makes it a critical intermediate for introducing fluorinated motifs into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop new compounds with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in the creation of fluorinated drug candidates for oncology, CNS, and antiviral therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorination can improve biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Serves as a building block for fluorinated liquid crystals and organic semiconductors used in display technologies and electronic devices.
• Organic Synthesis & Catalysis: Employed as a versatile reagent in cross-coupling reactions and as a ligand precursor in organometallic chemistry and catalysis.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the development of specialty polymers with unique surface properties, chemical resistance, and thermal stability.

Basic Information

Product Name	2,3,4,5-Tetrafluoropyridine
CAS No.	3512-16-1
Molecular Formula	C5HF4N
Molecular Weight	151.06 g/mol
Synonyms	2,3,4,5-Tetrafluoropyridine; Perfluoropyridine (incorrect but common alias); Tetrafluoropyridine; Pyridine, 2,3,4,5-tetrafluoro-; 3512-16-1; NSC 406908; AS-68337; BCP31963; SCHEMBL1184151; ZINC000005014761
EINECS	Contact for details

Quality Control

Our 2,3,4,5-Tetrafluoropyridine is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.