Description

2,4,6-Trifluoropyridine-3-Carboxylic Acid is a high-value fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique trifluoromethylated structure provides enhanced metabolic stability and lipophilicity, making it indispensable for creating novel compounds with targeted properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of novel fluorinated polymers, liquid crystals, and electronic materials.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	2,4,6-Trifluoropyridine-3-Carboxylic Acid
CAS No.	3512-14-9
Molecular Formula	C6H2F3NO2
Molecular Weight	177.08 g/mol
Synonyms	3-Carboxy-2,4,6-trifluoropyridine; 2,4,6-Trifluoropyridine-3-carboxylic acid; 2,4,6-Trifluoronicotinic Acid; 3-Pyridinecarboxylic acid, 2,4,6-trifluoro-; Nicotinic acid, 2,4,6-trifluoro-
EINECS	Contact for details

Quality Control

Every batch of 2,4,6-Trifluoropyridine-3-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed HPLC purity, NMR, and MS data are supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.